Orthopedic filler

Durolane It is intended for the Usonelle Injections in the intra -articulation for the symptomatic treatment of osteoarthritis of the knee or hip from mild to moderate.In addition, it is intended for use in intra -articular injections for the symptomatic treatment of osteoarthritis of the synovial joints indicated by mild to moderate and for the reduction of pain following arthroscopic procedures.The product must be injected by a competent doctor or in accordance with local legislation. Durolane Contains 20 mg/ml of non -animal hyaluronic acid stabilized in physiological solution of sodium chloride pH 7. It is a sterile transparent elastic gel supplied in a 3 ml glass syringe.The product is exclusively disposable.Hyaluronic acid is identical in all living organisms.It is a natural polysaccharide present in the body's tissues, with particularly high concentrations in synovial liquid and skin. Durolane It is composed of hyaluronic acid biosyntically, purified and stabilized product. Durolane It is assimilated by the body according to the same metabolic path as endogenous hyaluronic acid.

Content
Each ml contains:
20 mg stabilized hyaluronic acid, physiological solution of sodium chloride, pH 7q.s.

Method of action
The hyaluronic acid of the body constitutes a natural part of the synovial liquid and acts in the joints both as a cartilage lubricant and ligaments and as a shock absorber.Hyaluronic acid injections in the articulation to restore viscosity and elasticity can reduce pain and improve the mobility of the joint.

Format
Packaging:
The Durolane is supplied in a 3 ml glass syringe with Luer-Lok connection, Blister's unconfection.The content of the syringe is sterile.The external part of the excess is not sterile.

Synvisc It is composed of Hylan G-F 20 is a sterile viscoelastic liquid, apoish, containing Hylan.Hylan G-F 20 temporarily reconstitutes the viscoelasticity of the synovial liquid, brings clinical benefits to patients in all stages of arthrosis of the joints, is more effective in patients who actively and regularly use the articulation affected by the pathology, and reaches its therapeutic effect through theViscosupplementation, a process through which the physiological state and the retiological characteristics of the synovial fluid of the arthritic articulation are reintegrated.Hylan are derived from hyaluronate (sodium salt of hyaluronic acid) and are made up of unconventional unconventive units of n-acetylglucosamine and sodium glucuronate.Hylan A has an average molecular weight of about 6,000,000 Dalton and Hylan B is an hydrogel.Hylan G-F 20 contains Hylan A and B (8.0 mg ± 2.0 mg per ml) in sodium chloride buffered physiological solution (pH 7.2 ± 0.3).
Viscosupplement with Hylan G-F 20 is indicated to relieve pain and functional limitations, allowing a more extensive movement of the joint.In vitro studies have shown that Hylan G-F 20 protects cartilage cells from damage due to the action of physical and chemical agents.
Synvisc-One is indicated only for the intra-articular use by a doctor in the treatment of pain associated with knee arthrosis.

Dosage
The dosage scheme of Hylan G-F 20 depends on the joint to be treated. 
Knee arthrosis: recommended treatment regime for Synvisc is three injections of 2 ml in the knee, after a week from each other.To achieve the optimal effect, it is essential to practice all three injections.The recommended maximum dosage is six injections over six months, with a pause of at least four weeks between the treatment regimes.
Artosis of the hip, ankle and shoulder: recommended initial treatment regime is a single injection of 2 ml.However, it is recommended to practice a second injection of 2 ml if an adequate symptomatic benefit of pain is not obtained.Clinical data have shown that patients benefit from this second injection if practiced after one-three months from the first
Generally a maximum duration of the effect has been found for patients who respond well to treatment up to 26 weeks, even if shorter or longer periods have been observed.Data extrapolated from perspective clinical studies conducted on patients with knee arthrosis have shown treatment benefits of up to 52 weeks, after a single treatment cycle of three synvisc injections.

Ingredients/INCI
Each ml contains: Hylan 8.0 mg, sodium chloride 8.5 mg, disodium phosphate hydrogen 0.16 mg, dioxide sodium phosphate hydrated 0.04 mg, water for preparations injectable enough.

Format
Package with 3 glass syringes of 2.25 ml caduna pre -rated with 2 ml caduna.of Hylan G-F 200. Store at a temperature between +2 ° C and +30 ° C.Do not freeze.

Synvisc is composed of Hylan G-F 20 is a sterile viscoelastic liquid, apoish, containing Hylan.Hylan G-F 20 temporarily reconstitutes the viscoelasticity of the synovial liquid, brings clinical benefits to patients in all stages of arthrosis of the joints.

Idrogel biocompatibile di sodio ialuronato cross-linkato ottenuto mediante biofermentazione e altamente purificato, disciolto in un tampone fisiologico e isotonico. Il prodotto è un idrogel iniettabile, sterile e apirogeno, con un basso livello di endotossine.
JONEXA UP è formulato con sodio ialuronato altamente purificato, sali di qualità conforme ai requisiti riportati in Farmacopea e acqua per preparazioni iniettabili.
JONEXA UP riduce il dolore e aumenta la funzionalità dell'articolazione interessata.
JONEXA UP fornisce un effetto lubrificante e di assorbimento degli urti sull’articolazione interessata.
JONEXA UP migliora la qualità di vita del paziente.
JONEXA UP deve essere somministrato mediante iniezione intra-articolare da un medico qualificato seguendo tutte le regole riguardanti la procedura asettica e la tecnica di iniezione.
JONEXA UP deve essere iniettato con un ago sterile adatto (si raccomandano aghi 18-21G).
Si raccomanda la somministrazione di JONEXA UP in un'unica seduta. La quantità di prodotto da somministrare è a discrezione del medico specialista. Eliminare qualsiasi parte inutilizzata della siringa.

Cingal è una siringa pre-riempita a base di acido ialuronico in grado di agire come sostituto del liquido sinoviale nei trattamenti intra-articolari e per questo molto utile in caso di osteoartrosi.
La sua composizione, infatti, è capace di ripristinare le proprietà visco-elastiche del liquido presente nelle articolazioni.
Quindi, essendo in grado di migliorare la lubrificazione e la protezione delle articolazioni dagli stress meccanici, può essere utilizzato in caso di artrosi ma anche per affezioni degenerative, post-traumatiche o alterazioni delle articolazioni.